An Observational Study to Evaluate the Clinical Utility of the Oncomine Precision Assay Within the Exactis Network

Inclusion Criteria

• •Patients with NSCLC, which is (i) advanced or metastatic (stage IIIb/IV), (ii) non- squamous histology NSCLC as confirmed by local histopathology (mixed squamous and adenocarcinoma is allowed), and has (iii) radiographically measurable disease with at least one bidimensionally measurable lesion of \> 1 cm by CT scan
• •No prior treatment for advanced or metastatic NSCLC, except for palliative radiation therapy to non-lung or non-thorax metastases. Patients who received palliative radiation therapy to metastases located within or approximately to the lung or thorax must be evaluated for eligibility.
• •Willing and able to provide adequate blood sample prior to starting treatment.
• •Willing to provide primary or metastatic tissue, if available.
• •Signed and dated Research Ethics Board (REB)-approved informed consent form for Exactis-01 or PMT.
• •Not pregnant or breastfeeding