Diabetes Prevention Program (METFIT) in Reducing Insulin Resistance in Stage I-III Breast Cancer Survivors

Women who have been treated definitively for early stage breast cancer (I-III) and are 60-180 days from completion of chemotherapy, radiation and surgery regardless of hormonal status

Demonstrated at least a 10% weight gain since being diagnosed with breast cancer

Demonstrated IR by having a Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score of \>= 2.0

Demonstrated IR manifested by meeting criteria for metabolic equivalent (MetS) as defined by modified criteria of the National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) (2005 version) and the World Health Organization (WHO) which includes:

* Dysregulation of glucose homeostasis demonstrated by a glycosylated hemoglobin (HbA1c) \>= 6.5%; OR fasting plasma glucose \>= 126 mg/dl (7.0 mmol/L) OR random plasma glucose \>= 200 mg/dL (11.1 mmol/L)

* Plus two of any of the following:

* Waist circumference in men \>= 40 inches and in women \>= 35 inches

* Elevated triglycerides \>= 150 mg/dL

* Low high-density lipoprotein (HDL) cholesterol in men \< 40 mg /dL and in women \< 50 mg/dL or taking statin medication

* Elevated blood pressure defined by a systolic pressure \>= 130 of a diastolic pressure \>= 85 mm Hg or taking anti-hypertensive medication

* Elevated fasting glucose \>= 110 mg/dL

Non-smoker (last use 6 months prior to enrollment into the study)

Documented informed consent of the participant and/or legally authorized representative

Willingness to make substantial changes in their dietary and physical activity behavior

Willingness to attend at 70% of the intervention sessions and 100% of the blood draws

The effects of IF on the developing fetus of breast cancer survivors are unknown. For this reason, women of child bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating in the trial, should inform her treating physician immediately

Willingness to weigh themselves weekly

Willingness to wear a subcutaneous continuous glucose monitor

Access to an electronic virtual teleconferencing device and capacity to utilize electronic teleconference technology

What this study is about