Pharmacological Modulation of Hippocampal Activity in Psychosis 2

Inclusion Criteria

• •1. Men and women age 18 - 65.
• •2. Communicative in English.
• •3. Provide voluntary, written informed consent.
• •4. Physically healthy by medical history.
• •5. BMI \> 17.5 and \< 45.
• •6. Diagnosis of a psychotic disorder confirmed by Structured Clinical Interview for Diagnostic and Statistical Manual-5 (SCID) or diagnostic interview with a trained clinician.
• •7. Stable medication regimen over at least the past two weeks, including the use of either an oral or intramuscular administration of an antipsychotic medication.
• •8. For females, no longer of child-bearing potential, or agreeing to practice effective contraception during the study (e.g., established use of oral, injected or implanted hormonal methods of contraception; placement of an intrauterine device or intrauterine system; barrier methods: condom with spermicidal foam/gel/film/cream/suppository or occlusive cap \[diaphragm or cervical/vault caps\] with spermicidal foam/gel/film/cream/suppository; male partner sterilization; or true abstinence when this is in line with the preferred and usual lifestyle of the subject); and,
• •9. For females of child-bearing potential, must have a negative urine pregnancy test before MRI and drug administration.
• •10. Not breastfeeding/nursing at time of screening or at any time during the study.
• •1\. All of the above except for subjects will be psychiatrically healthy and not taking psychotropic or potentially psychoactive prescription medication.
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