Left Atrial Appendage Closure as Secondary Prevention of Atrial Fibrillation-related Embolic Events

Exclusion Criteria

• •Valvular AF (after moderate to severe mitral stenosis or mechanical valve replacement)
• •Initial AF, reversible AF with clear cause
• •Presence of adherent thrombus in the left atrium or left ventricular aneurysm thrombus
• •ST elevation myocardial infarction, ≤ 3 months
• •Grade-IV of Cardiac Function (NYHA)
• •Allergy or contraindication to metal nitinol, aspirin, clopidogrel, heparin, and other anticoagulants
• •Pregnant or with plan of pregnancy during the study
• •Participation in another drug or medical device clinical trial or study that has not been completed
• •Experience new stroke or TI within 30 days or major bleeding events within 14 days
• •Contraindication to LAA closure or deemed unsuitable for study participation by the investigator
• •Had a definite thromboembolic event