Assessment of Early Vascular Damage With Advanced Neuroimaging in Patient With Patent Foramen Ovale

Exclusion Criteria

• •previous IMA, stroke or TIA
• •arrhythmia or severe cardiac disease
• •hypertension, diabetes or renal disease
• •psychiatric disease
• •neurological or neurodegenerative disease
• •dementia
• •assumption of drugs known to interfere with cognitive function
• •inability to be subjected MRI analysis
• •participation to other clinical trial, ongoing or terminated less than one month before enrolment in this study.