Neuroinflammation and Age-associated Brain Pathology: Two Potential Mechanisms of Cognitive Impairment in Ovarian Cancer

Exclusion Criteria

• •1. Contraindication to MRI
• •2. Pregnancy
• •3. Lactation
• •4. Individuals who are unable to participate in the imaging portion due to severity of their medical condition
• •5. Chronic infectious disease (e.g. HIV, HCV)
• •6. Chronic inflammatory disease (e.g., fibromyalgia, MS, etc) or autoimmune disease
• •7. Viral or bacterial illness requiring medical attention and/or antibiotics within 1 month of study participation
• •8. Blood or blood clotting disorder
• •9. Cancer that has metastasized to the brain
• •10. Positive urine hCG test day of procedure or a serum hCG test within 48 hours prior to the administration of \[18F\]DPA-714 and \[11C\]PiB.
• •11. Currently enrolled in a clinical trial utilizing experimental therapies.
• •12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.
• •13. Prior brain tumor or other neurological condition known to affect cognition
• •14. A diagnosis of dementia unrelated to cancer or an adjusted MMSE score \< 24