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Intraoperative Hemodynamic Optimization: Predictive Value to Fluid Respon-siveness of the Tidal Volume Challenge and the Lung Recruitment Maneuver by Monitoring the Variation of the Pulsed Pressure and the Variation of the Systolic Ejection Volume.
In order to predict fluid responsiveness in the operating room and therefore benefit of performing fluid administration to improve patient's hemodynamic status, it will test two ventilation strategies : the Tidal Volume Challenge (VtC) and the Lung Recruitment Maneuver (LRM). The objective is to determine whether the variation of 2 parameters such as pulse pression variation (PPV) and stroke volume variation (SVV) during these 2 strategies, allows to predict fluid responsiveness in the operating room for any heavy surgery. All patients will benefit from the 2 ventilation strategies then a fluid administration, called " fluid challenge ", will be performed to discriminate the true responders and others. The order of the ventilation strategies will be determined by randomization.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
Hop Claude Huriez Chu Lille
Lille, France
Start Date
November 15, 2020
Primary Completion Date
July 17, 2021
Completion Date
July 17, 2021
Last Updated
January 26, 2023
160
ACTUAL participants
Starting LRM (Lung Recruitment Maneuver)
PROCEDURE
Starting VtC (Tidal Volume Challenge)
PROCEDURE
Lead Sponsor
University Hospital, Lille
NCT04419480
NCT07270341
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