Convalescent Plasma as Potential Therapy for Severe COVID-19 Pneumonia

Inclusion Criteria

• •Adult patients ≥18, and non-pregnant women
• •Severe or critical COVID-19 disease define by one or more of the following: blood oxygen saturation ≤ 94% on supplemental oxygen by nasal cannula at least 3 L/min, non-rebreathing mask (NRO2-mask) or on noninvasive ventilation; and pulmonary infiltrates with \>50% increase within 24 to 48 hours in chest-X-ray or chest CT. Life-threatening disease was defined as one or more of the following: respiratory failure on mechanical ventilation with PaO2 / FiO2 less than 300 mm Hg, septic shock, and/or multiple organ dysfunction.
• •* 10 days from the onset of symptoms or ≤ 7 days on mechanical ventilation. -