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Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor In Primigravidas
To compare propranolol and misoprostol versus misoprostol alone for induction of labour in primigravidas
Candidates will be randomized into 2 groups according to a computer generated sequence. Each candidate will be assigned an opaque sealed envelope containing a paper with her group on it. Both the patient and doctor on duty will be blinded to which group the patient was assigned to. \- Study procedure: 1. Written informed consent will be obtained from all participants prior to the study. 2. Full history taking. 3. General examination. Patients will be subjected to the following: * Patients attending labour room for induction of labour will be divided into two groups. * Both groups, women are induced with Tab misoprostol 25μg applied to posterior vaginal fornix under aseptic precaution and every 6 hours for a maximum of 4 doses. * In group 1, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral Propanolol 20mg * In group 2, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral placebo in the form of sugary tablets. * After induction, women will be monitored for fetal and maternal wellbeing and progress of labour.
Age
18 - 45 years
Sex
FEMALE
Healthy Volunteers
Yes
Ahmed mohamed fathy ismail
Zagazig, El Sharquia, Egypt
Start Date
February 1, 2020
Primary Completion Date
September 13, 2020
Completion Date
September 15, 2020
Last Updated
August 31, 2022
128
ACTUAL participants
Misoprostol
DRUG
Placebo
DRUG
Propranolol
DRUG
Lead Sponsor
Ahmed mohamed fathy ismail
Collaborators
NCT05622968
NCT03086967
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT04496908