Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance

Inclusion Criteria

• •HISTORY
• •no personal history of chronic disease, except well controlled thyroid disease
• •no history of diabetes in a first degree relative, including gestational diabetes
• •no family or personal history of hyperlipidemia
• •normal timing of menarche (age 10-14)
• •normal menstrual cycles (q25-35 days)
• •no use of contraceptive pills, patches or vaginal rings within last 4 weeks
• •nulliparous (no history of a pregnancy)
• •no active illicit drug use
• •no history of a medication reaction requiring emergency medical care
• •no difficulty with blood draws
• •stable weight for previous three months
• •available for all parts of the study
• •PHYSICAL
• •body mass index (18.5-25)
• •systolic BP \< 120mm Hg, diastolic \< 80 mm Hg
• •normal waist circumference (less than 32 inches)
• •LABORATORY STUDIES: (per Massachusetts General Hospital reference ranges)
• •fasting LDL cholesterol less than 130 mg/dL
• •fasting triglycerides less than 150 mg/dL
• •normal hemoglobin
• •hemoglobin A1C \< 5.7%
• •blood urea nitrogen, creatinine not elevated
• •AST, ALT not elevated
• •negative serum pregnancy test