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RECRUITINGNCT04530760

Intraabdominal Hypertension and Occurrence of Microaspiration in Cirrhotics Under Mechanical Ventilation

The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.

Lead sponsor: University Hospital, Lille•2 locations•View source on ClinicalTrials.gov

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Contacts

Saad Nseir, MD,PhD

CONTACT

0320444495 saadalla.nseir@chru-lille.fr

Sponsors

Lead Sponsor

University Hospital, Lille

Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation. Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•adult patients
•Cirrhosis
•intubation and mechanical ventilation

Exclusion Criteria

•pregnancy
•oliguric patients
•impossibility to measure intravesical pressure

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 23, 2025Terms

Trial snapshot

StatusRECRUITING

Phase—

Enrollment226

Start dateOct 2021

Last updatedDec 23, 2025

Condition

Critical Illness Cirrhosis, Liver

Locations shown

Hop Claude Huriez Chu Lille

Lille

Hop Salengro - Hopital B

Lille

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 23, 2025Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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