2. Meeting with the criteria of major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5;
3. Scored 20 or higher on the Hamilton's Depression Scale with 24 items (HAMD-24);
4. With enough audio-visual ability and comprehensive ability to accomplish the visits;
5. No medication or washout period of at least 2 weeks
6. Scored less than 14 on the Hypomania Symptom Checklist-32 (HCL-32);
You may not be if
1. Existing serious and active physical diseases that may interfere with treatment (abnormal indicators\> 2 times the normal value), or there is a pharmacological conflict between the current medical medication and the study drug;
2. Previous mania or hypomania episodes;
3. Female patients who are pregnant, planning to be pregnant or breastfeeding;
4. Current high suicide risk (e.g. 3rd item of HAMD-24 scored≥3(suicidality));
5. Had ECT, MECT or rTMS in the past 6 months;
6. Experienced a history of dependence on psychoactive substances, organic mental disorders, personality disorders, mental retardation, neurodegenerative diseases, brain trauma and cerebrovascular diseases.
Clareo Health | Optimization of Diagnosis and Treatment of Depression Based on Multidimensional Clinical Assessment Classification
