Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Ruijin Hospital
Age
18–65
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
MS Patients Group:
between 18-65 years old;
diagnosed with mild or moderate disease (EDSS score ≤ 5 points); it meets the 2017 new version of McDonald diagnostic criteria for multiple sclerosis.
meet the diagnostic criteria of clinically isolated syndromes (CIS)
between 18-65 years old;
able to understand the purpose of clinical research and test plan;
In the brain MR assessment, it is judged as "normal (corresponding to age)"
You may not be if
No brain surgery/no brain trauma/no history of brain disease (stroke), no other independent neurological or psychiatric history;
No severe depression symptoms;
No alcoholism or drug dependence (addiction);
No other conditions that affect the smooth progress of the inspection: such as hearing impairment, comprehension impairment, poor compliance, etc.;
No rheumatic diseases and other acute or chronic inflammations (required for hematological markers).
No MR contrast agent allergy
Healthy Volunteers Group:
Any major mental illness; history of schizophrenia or schizoaffective disorder
Any important neurological disease, such as cerebrovascular disease, inflammation or infectious disease, demyelinating disease, neurodegenerative disease, history of epilepsy or history of physical or craniocerebral trauma or brain surgery or intracranial hematoma with permanent brain history of injury;
Brain MR has pathological manifestations;
Any major diseases or unstable conditions (such as unstable angina, myocardial infarction or coronary revascularization within 12 months before enrollment, heart failure, chronic renal failure, chronic liver disease, severe lung disease, blood disease, poorly controlled diabetes, chronic infections);
Medical history of tumors (except skin or prostate cancer in situ) within 5 years before screening;
High risk of drug allergy (such as patients with allergic asthma) or history of severe allergic reactions to allergens;
History of alcohol or drug abuse/dependence;
MR contraindications (such as pacemaker or nerve stimulator or metal foreign body, high fever, etc.)
