Accurate Diagnosis of Multiple Sclerosis Using PET/MR

Exclusion Criteria

• •No brain surgery/no brain trauma/no history of brain disease (stroke), no other independent neurological or psychiatric history;
• •No severe depression symptoms;
• •No alcoholism or drug dependence (addiction);
• •No other conditions that affect the smooth progress of the inspection: such as hearing impairment, comprehension impairment, poor compliance, etc.;
• •No rheumatic diseases and other acute or chronic inflammations (required for hematological markers).
• •No MR contrast agent allergy
• •Healthy Volunteers Group:
• •Any major mental illness; history of schizophrenia or schizoaffective disorder
• •Any important neurological disease, such as cerebrovascular disease, inflammation or infectious disease, demyelinating disease, neurodegenerative disease, history of epilepsy or history of physical or craniocerebral trauma or brain surgery or intracranial hematoma with permanent brain history of injury;
• •Brain MR has pathological manifestations;
• •Any major diseases or unstable conditions (such as unstable angina, myocardial infarction or coronary revascularization within 12 months before enrollment, heart failure, chronic renal failure, chronic liver disease, severe lung disease, blood disease, poorly controlled diabetes, chronic infections);
• •Medical history of tumors (except skin or prostate cancer in situ) within 5 years before screening;
• •High risk of drug allergy (such as patients with allergic asthma) or history of severe allergic reactions to allergens;
• •History of alcohol or drug abuse/dependence;
• •MR contraindications (such as pacemaker or nerve stimulator or metal foreign body, high fever, etc.)