Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

Inclusion Criteria

• •Post-menopausal females (as defined by lack of menstruation for 12 months or status post oophorectomy)
• •Histologic or pathologic diagnosis of stage III-IV epithelial ovarian, fallopian tube, or primary peritoneal cancer
• •Eastern Cooperative Oncology Group (ECOG) ≤2
• •Life expectancy \> 1 year
• •Status post cytoreductive surgery for ovarian cancer or with planned cytoreductive surgery if treated with neoadjuvant chemotherapy
• •Prescribed a minimum of six cycles of platinum-based chemotherapy
• •Adequate organ function as defined below:
• •1. Hemoglobin \> 9 g/dL
• •2. Leukocytes \>1,500/mcl
• •3. Absolute Neutrophil Count \> 1,000/mcL
• •4. Platelets \> 125,00/mcL
• •5. total bilirubin Within normal institutional limits
• •6. Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) \< 2.5 x institutional upper limit of normal
• •7. Serum creatinine \< 1.5 mg/dL.