Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Catharina Ziekenhuis Eindhoven
Age
50–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Age ≥ 50 years
Moderate aortic stenosis confirmed in the past 3 months by standard echocardiographic evaluation: aortic valve area \>1.0 cm2 plus either maximal velocity 2.5-3.9 m/s or mean gradient 15-39 mmHg
Ability to undergo exercise stress testing
Ability to understand and the willingness to provide written informed consent
You may not be if
A potential subject who meets any of the following criteria will be excluded from participation in this study
Any hemodynamic criterion for severe AS: maximal velocity \>= 4 m/s, mean gradient \>= 40mmHg, aortic valve area =\< 1 cm2
Percutaneous coronary intervention or coronary artery bypass grafting in the past three months, or have revascularization planned in the near future
Known, unrevascularized, and severe coronary artery disease (for example a 90% diameter stenosis or FFR\<0.7 in the proximal left anterior descending artery)
Impaired left ventricular function (ejection fraction \<50%)
Unicuspid, bicuspid, or non-calcified aortic valve observed during echocardiography (note that later cusp fusion noted during study-related cardiac imaging will not exclude a subject)
Severe aortic regurgitation, mitral valve disease, tricuspid regurgitation, or a significant intracardiac shunt
Co-existing hypertrophic cardiomyopathy or severe septal hypertrophy \>15mm
Persistent atrial fibrillation with uncontrolled ventricular response
Recent (within 6 weeks) acute coronary syndrome
Estimated glomerular filtration rate ≤30 mL/min or end-stage renal disease on replacement therapy (dialysis)
Severe COPD GOLD stage 3 or 4, home oxygen dependence, or ≥2 pulmonary inhalers (note that well-treated and stable asthma and GOLD stage 1 or 2 COPD is permitted)
Severe comorbid condition with life expectancy \<2 years
Prior adverse reaction to dobutamine
Severe iodine contrast allergy
Pregnancy
Severe pulmonary hypertension with systolic pulmonary artery pressure greater than 50mmHg or isolated and symptomatic right ventricular failure
Clareo Health | Stress Aortic Valve Index for Assessing Risk in Aortic Valve Stenosis Patients
