Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Illinois at Chicago
With
National Institute on Drug Abuse (NIDA)
Age
18–25
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
must be able to give informed consent
age 18-25 at the time of signing the consent form
fluency in English
body mass index of 19-26 (normal/overweight but not obese due to limitations of MRI)
negative urine drug screen (UDS) for all substances except THC (THC allowed)
must be medically and neurologically healthy
must not be taking psychoactive medications that would interfere with dronabinol and/or interpretation of fMRI data, including but not limited to the following classes of psychotropics: antidepressants, anxiolytics, sedative hypnotics, stimulants, antipsychotics, mood stabilizer
have used cannabis at least 10 times in their life, but report current and past lifetime cannabis use less than 7 days/week (daily)
You may not be if
any current medical condition requiring psychoactive/psychotropic medication or medication that would interact with dronabinol, interpretation of fMRI data, and/or interfere with study procedures
current or past allergic or adverse reaction or known sensitivity to cannabinoid-like substances (Dronabinol/Marijuana/Cannabis/THC, cannabinoid oil, sesame oil, gelatin, glycerin, and titanium dioxide.)
current Axis-I Diagnostic Statistical Manual-5 diagnosis (although mild and moderate Cannabis Use Disorder (CUD) and mild and moderate Alcohol Use Disorder (AUD) are allowed)
score \>3 on the Prediction of Alcohol Withdrawal Severity Scale (PAWSS) for individuals with current AUD
lifetime other lifetime Substance Use Disorder (although lifetime severe CUD and lifetime severe AUD are allowed)
currently seeking or engaged in CUD treatment or have desire to cut down or stop cannabis use.
in recovery or enrolled in treatment for any substance (including cannabis and alcohol)
lifetime psychosis, mania, Attention-Deficit/Hyperactivity Disorder, Obsessive-Compulsive disorder, Feeding and Eating disorder, or Post-Traumatic Stress Disorder
score \>7 on the Hamilton Depression Rating Scale or score \>7 on the Hamilton Anxiety Rating Scale
less than a high school education
lack of fluency in English
night shift work
currently pregnant confirmed by urine pregnancy test or planning pregnancy or lactating (women)
unwilling/unable to sign informed consent document
inability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report
left-handed
presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)
positive UDS for any drug except THC
positive breathalyzer for acute alcohol intoxication
heavy alcohol use (\>4 days week) in the past month
heavy nicotine use (\>20 cigarettes per week) in the past month
Clareo Health | Reward and Drug Effects on Mood and Brain Response
