Childhood Cancer Predisposition Study (CCPS)

You may be eligible if

• Primary Subjects must meet all of the below criteria to be eligible for enrollment:
• 1. Be less than 21 years of age at the time of enrollment
• 2. Have a diagnosis of a specific CPS, whether they have had cancer or not
• * Based on clinical laboratory testing demonstrating a Pathogenic or Likely Pathogenic germline variant and/or
• * Based on well-established clinical diagnostic criteria and/or
• * Based on high clinical suspicion of a specific CPS with clinical laboratory testing demonstrating a variant of uncertain significance (VUS)
• Affected Parents must meet all of the following criteria to be eligible for enrollment:
• 1. Be the biologic parent of a Primary Subject and
• 2. Carry a diagnosis (or obligate diagnosis) of the familial CPS
• Adult Affected Siblings must meet all of the following criteria to be eligible for enrollment:
• 1. Be the biologic sibling of a Primary Subject and
• 2. Carry a diagnosis (or obligate diagnosis) of the familial CPS
• Unaffected Parents and Siblings must meet all of the following criteria to be eligible for enrollment
• 1. Be the biologic parent or sibling of a Primary Subject and
• 2. Not carry a diagnosis (or obligate diagnosis) of the familial CPS
• Affected Family Members must meet all of the following criteria to be eligible for enrollment:
• 1\. Carry a diagnosis of (or obligate diagnosis of) the familial CPS. Documentation is requested but not required.
• More than one child from a Primary Family Unit may be a Primary Subject. An Unaffected Sibling may be reclassified as a Primary Subject if diagnosed with a CPS during childhood.