About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Lundbeck TOMs Orthostatic Hypotension | Clinical Trials | Clareo Health

Back to clinical trial search

COMPLETEDPhase 4NCT04510922

Lundbeck TOMs Orthostatic Hypotension

Orthostatic hypotension (OH), which consists in a significant reduction in blood pressure levels upon standing from a seated position, may affect approximately one in three patients with Parkinson's d...

Lead sponsor: Alberto Espay, MD, MSc•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Clareo turns complex medical information into clear understanding you can use.

Bring this clarity to your next appointment.

Keep all your medical notes and next steps in one place.

Sponsors

Lead Sponsor

Alberto Espay, MD, MSc

Collaborators

Lundbeck LLC

Age

30 - 80 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Diagnosis of idiopathic Parkinson's Disease, meeting UK Brain Bank criteria for at least 3 years
•Hoehn and Yahr (H\&Y) stage I-III
•Age between 30 and 80 years old (both inclusive)
•Stable dosage of dopaminergic medications for at least 4 weeks
•Orthostatic Hypotension, defined as a fall in systolic BP ≥ 20 mmHg or diastolic BP ≥ 10 mmHg within 3 minutes of standing
•Willingness and ability to comply with scheduled visits

Exclusion Criteria

•Diabetes mellitus or other diseases potentially associated with autonomic dysfunction
•Treatment with antihypertensive drugs or with alpha-adrenergic antagonists
•Cognitive impairment, defined as a score \< 24 at the Montreal Cognitive Assessment (MoCA)
•Any atypical signs lowering the diagnostic certainty for PD
•Lack of postural reflex defined as a score \> 2 at the MDS-UPDRS item 3.12 (recover at the pull test)
•Severe levodopa induced dyskinesia, defined as an MDS-UPDRS item 4.2 \> 2 (functional impact of dyskinesia)

Related studies

RECRUITINGPhase 2

A Study in Subjects With Neurogenic Orthostatic Hypotension

NCT07089043 · Neurogenic Orthostatic Hypotension

RECRUITINGPhase 1

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

NCT02429557 · Orthostatic Hypotension, Pure Autonomic Failure, and more

RECRUITINGEARLY Phase 1

Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients

NCT04620382 · Neurogenic Orthostatic Hypotension, Autonomic Failure, and more

RECRUITINGPhase 1

Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure

NCT02897063 · Autonomic Failure, Pure Autonomic Failure, and more

POLish Registry of CArdioneuroablation and CArdioneuromodulation

NCT07196397 · Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, and more

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 26, 2022Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment9

Start dateFeb 2019

Last updatedSep 26, 2022

Condition

Orthostatic Hypotension Idiopathic Parkinson Disease

Locations shown

University of Cincinnati

Cincinnati, Ohio

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 26, 2022Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions