Immune Checkpoint Inhibitor In High Risk Oral Premalignant Lesions

Exclusion Criteria

• •1. Previous immunotherapy (anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antibody or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint receptors);
• •2. Oral lesions due to lichen planus;
• •3. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy, or known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness;
• •4. Any test for hepatitis B virus (HBV) or hepatitis C virus (HCV) indicating acute or chronic infection;
• •5. Vaccination within 4 weeks of the first dose of avelumab and while on trial is prohibited except for the administration of inactivated vaccines (for example, inactivated influenza vaccines);
• •6. Clinically significant cardiovascular disease, e.g. cardiac failure of New York Heart Association classes III-IV, uncontrolled coronary artery disease, cardiomyopathy, uncontrolled arrhythmia, uncontrolled hypertension, or history of myocardial infarction in the last 12 months;
• •7. Significant neurologic or psychiatric disorders including dementia or seizures;
• •8. Active uncontrolled infection (requiring IV antibiotics) or active tuberculosis;
• •9. Active disseminated intravascular coagulation;
• •10. Other serious underlying medical conditions which could impair the ability of the patient to participate into the study;
• •11. Having participated in another clinical trial or having received any investigational agent in the preceding 30 days before study entry;
• •12. Known allergic/hypersensitivity reaction to any of the components of the treatment;
• •13. Pregnancy (absence confirmed by serum/urine beta HCG) or breastfeeding;
• •14. Other active malignancy within 3 years, with the exception of a history of a previous, adequately treated:
• •* basal cell carcinoma of the skin
• •* pre-invasive carcinoma of the cervix
• •* superficial bladder cancer
• •* carcinoma in situ of the prostate, cervix or breast,
• •* head and neck squamous cell carcinoma, surgically treated (radiotherapy treatment not allowed);
• •15. Legal incapacity or limited legal capacity;
• •16. Medical, psychological or socio-geographical condition or situation which in the opinion of the investigator would not permit the patient to complete the study or sign meaningful informed consent;
• •17. Active, known or suspected autoimmune disease. Patients with vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger are permitted to be enrolled;
• •18. Conditions requiring systemic treatment with either corticosteroids (\> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 7 days of study drug administration. Inhaled or topical steroids, steroids as premedication for hypersensitivity reactions and adrenal replacement doses \> 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease.