A Study of LY3451838 in Participants With Migraine

Exclusion Criteria

• •Are currently enrolled in any other clinical study or any other type of medical research judged not to be compatible with this study.
• •Have participated, within the last 30 days or 5-half-lives (whichever is longer), in a clinical study involving any investigational product. If the half-life of the investigational product is unknown, 6 months should have passed prior.
• •Known hypersensitivity or intolerance to monoclonal antibodies or other therapeutic proteins, or to common antihistamines, epinephrine, methyl prednisone or other systemic corticosteroids.
• •Are currently receiving medication or other treatment for prevention of migraine headaches. Participants must have discontinued such medications or treatments at least 2 weeks prior. Botulinum toxin A or B that has been administered in the head or neck area use must be discontinued at least 3 months prior. Nerve blocks or device use (such as transcranial magnetic stimulation or electrical nerve stimulation) in the head or neck area for migraine treatment must be discontinued at least 30 days prior. Anti-calcitonin gene-related peptide (CGRP) antibodies must be discontinued at least 5 half-lives prior.
• •Have previously failed more than 4 migraine preventive medication categories in the past 10 years due to inadequate efficacy (that is, maximum tolerated dose for at least 2 months) and/or safety / tolerability reasons.
• •History of cluster headache or migraine subtypes including hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, retinal migraine, typical aura without headache, complications of migraine and migraine with brainstem aura (basilar-type migraine).
• •In the 3 months prior, have other types of headache besides migraine, tension type headache, or medication overuse headache (MOH). (In other words, participants can have migraine, tension type headache, or MOH in the 3 months prior, but they cannot have other types of headache in that time).
• •History of head or neck injury within last 6 months.
• •History of traumatic cervical or head injury associated with significant change in the quality or frequency of headaches.
• •Have reading of electrocardiogram (ECG) showing abnormalities considered incompatible with the study.
• •Any liver tests outside the normal range.
• •Evidence of significant active or unstable psychiatric disease.
• •Women who are pregnant or nursing.
• •Participants who have used opioids or barbiturate-containing analgesic \>4 days per month for the treatment of pain in each of the past 3 months.
• •History of drug or alcohol abuse/dependence within 1 year.
• •Have a positive urine drug screen for illicit drugs.
• •Are unwilling or unable to comply with the use of data collection devices.