Ginkgo Leaf Extract and Armillariella Mellea Powder Oral Solution for the Treatment of Motoric Cognitive Risk Syndrome

Exclusion Criteria

• •Illiteracy
• •The Mini-Mental State Examination (MMSE) ≤ 23
• •Medical history of mental illness such as schizophrenia, severe anxiety and depression.
• •Medical history of Alzheimer's disease, Parkinson's disease, frontotemporal dementia or Huntington's disease.
• •Dementia caused by other causes (such as central nervous system trauma, tumor, infection, metabolic disease, normal pressure hydrocephalus, folic acid, vitamin B12 deficiency, thyroid Inferior functions, etc.).
• •History of epilepsy, or taking anti-epileptic drugs.
• •History of myocardial infarction or stroke
• •History of malignant tumor
• •Coagulation disorder, systemic bleeding; or previous coagulation disorder or systemic bleeding disease history.
• •History of thrombocytopenia or neutropenia.
• •History of blood system diseases or liver function abnormalities caused by medication
• •Contraindications to ginkgo drugs and a history of known allergies.
• •Aphasia, severe hearing or visual impairment, dominant hemiplegia, and other impacts on cognitive evaluation The status of the test.
• •Known slow gait causes (non-neurological causes \[such as: arthritis, heart disease\] and neurological causes \[bias Paralysis, ataxia, spasticity, Parkinson's disease and frontal lobe disease\])
• •Severe heart and lung diseases (coronary heart disease, LVEF\<40%, NYHA heart failure grade ≥III, asthma asthma).
• •Severe arrhythmia, heart rate \>120bpm or \<50bpm. (17) Blood pressure \<90/60mmHg
• •Severe anemia, Hb\<100g/L
• •Severe liver or renal insufficiency (ALT \> 2 times the upper limit of normal or AST \> 2 times the upper limit of normal; Creatinine \>1.5 times the upper limit of normal)
• •Leukopenia (\<2×109/l) or thrombocytopenia (\<100×109/l)
• •Currently enrolled in other drug or medical device study
• •Planned any surgery within 6 months at screening
• •Considered by investigators as unsuitable participant of this study