This is a randomized, double-blind, placebo controlled, parallel group design study aiming to compare the effects of minocycline 100mg twice daily vs matched placebo for 12 weeks on ambulatory BP and the parameters of sympathetic and immune activation
Age
45–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Aged: 45 -65 years
Signed informed consent
Clinical diagnosis of Resistant Hypertension
Daytime systolic ambulatory BP \>135mmHg.
You may not be if
History of myocardial infarction (MI) or any cardiovascular event within 3 months of screening period, clinically significant AV conduction disturbances and/or arrhythmias,
current of past history of heart failure (LVEF ≤40%)
psychotropic agents, antidepressants and NSAIDS
alcohol consumption of \>3 standard drinks.
known hypersensitivity or contraindication to minocycline or other tetracyclines.
