Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Colorado, Denver
With
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
The Specific Aims of This Study Are As Follows:
1. Identify whether sputum anti-CCP predicts incident RA
2. Determine the effect of inflammatory cytokines on the induction of NETosis in sputum neutrophils
3. Determine the role of sputum macrophage phagocytosis in NET clearance \<br\> The knowledge gained from this study will improve the overall understanding of the development of RA. It is anticipated that these findings will improve the field's understanding of how best to screen for RA risk and target RA prevention. This study could support future lung-targeted prevention strategies for RA that could avoid the administration of systemic toxic therapies. Such potential prevention interventions could be implemented in subjects at risk for RA in order to prevent the irreversible joint damage that can occur in the later stages of clinically-apparent RA.
Age
18–100
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Adults between 18 and 100 years;
At-Risk for RA, RA diagnosed, and Healthy Control subjects will be included in the study until recruitment goals are met for each group.
At-Risk:
1. No evidence of inflammatory arthritis on clinical examination AND
2. At elevated risk for RA based on familial or serologic risk
* Familial risk includes having a first degree relatives (FDRs) with RA
* Serologic risk includes asymptomatic serum ACPA positivity
Healthy Controls :
1. No history of RA
2. No FDRs with RA
3. No systemic use of immunosuppressants for autoimmune disease
RA Diagnosis:
1. Classified RA by 1987 ACR and/or 2010 ACR/EULAR RA classification criteria (confirmed by medical chart review) OR
2. Diagnosed with RA by a board-certified rheumatologist (confirmed by medical chart review)
If interested, please take a few minutes to complete the screening questionnaire for this study opportunity. You may open the survey in your web browser by clicking the link below:
https://is.gd/SPAROscreen
If the link above does not work, try copying the link below into your web browser:
https://redcap.ucdenver.edu/surveys/?s=3WM8WH3WKK
You may not be if
1. Currently pregnant or planning to become pregnant during the sample collection period of the study
2. Exacerbation of underlying obstructive lung disease within the past 1 month
3. Known FEV1 \<1 liter
4. Oxygen requirement \>2 liters at rest
5. Participants with health acuity or behavioral health concerns leaving them unable to participate in the current research
