Age

40–any

Sex

ALL

Healthy volunteers

Not accepted

At least 40 years
A smoking history
Smoking cessation ≥ 6 months
FEV1/FVC ≤ 0,7
Severe emphysema (destruction ≥ 50%)
Peak tricuspid regurgitation velocity \< 2,8 m/s or presence of other echocardiographic "PH signs"
15% ≤ FEV1post ≤ 50%
Residual volume ≥ 175% predicted
TLC ≥ 100% predicted
Optimal medical management
150m ≤ 6MWD ≤ 500m
mMRC ≥ 2
Physical activity ≥ 2/Week (≥ 30minutes)

Right Ventricular Diastolic Dysfunction