Medication Development for Protracted Abstinence in Alcoholism: CORT118335 Versus Placebo

Inclusion Criteria

• •Male or female volunteers, 18-75 years of age.
• •Meets DSM-5 criteria for current alcohol use disorder of moderate or greater severity (AUD-MS).
• •Subjects will not be seeking treatment because the medication studies are not treatment trials, and to avoid exposing treatment-seekers to alcohol cues.
• •Subjects must be abstinent a minimum of 3 days (but not more than 7 days) prior to the human lab session.
• •In acceptable health in the judgment of the study physician, based on interview, medical history, physical exam, ECG, routine urine and blood chemistry.
• •Subjects with a history of depression, who have been on a stable dose of anti-depressant medication for at least 3 months, and do not meet current DSM-5 criteria for depression or anxiety.
• •All subjects must agree to use double barrier birth control for the study duration and one month thereafter i.e., males must use condoms and females must use spermicide and/or a non hormonal barrier method, and their opposite sex partner must likewise use an effective non hormonal form of contraception.
• •Able to provide informed consent and understand questionnaires and study procedures in English.
• •Willing to comply with the provisions of the protocol and take daily oral medication