Lead Sponsor

National Institute of Cardiology, Warsaw, Poland

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•delivery of an informed consent and compliance with study protocol
•persistent angina pectoris (CCS class ≥2) refractory to optimal medical therapy
•CTO of a major coronary artery (left anterior descending artery, right coronary artery, left circumflex artery) of at least 2.5 mm vessel diameter confirmed by invasive angiography
•preserved left ventricular ejection fraction (\>50%) on echocardiography or cardiac magnetic resonance with preserved contractility in the CTO territory (normokinesia and/or hypokinesia)

•unstable angina and/or myocardial infarction
•prior myocardial infarction within 4 weeks before study enrolment
•occurrence of myocardial infarction and/or unplanned revascularization between the index procedure and post-procedural CTP study
•impaired renal function (eGFR ≤45 ml/min/m2)
•contraindications to antiplatelet therapy and/or heparin
•other contraindications to CTP (pregnancy, allergy to contrast media or pharmacologic stress agents, tachyarrhythmia, claustrophobia)

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