Postoperative Adjuvant Treatment of Completely Resected Mucosal Melanoma Phase II Study

Exclusion Criteria

• •1. Previously treated with anti-PD-1, anti-PD-L1, anti-PD-L2;
• •2. Known allergy to recombinant humanized anti-PD-1 monoclonal antibody drug and its components;
• •3. High dose of interferon therapy or adjuvant chemotherapy (Temozolomide + Cisplatin) was performed after surgery;
• •4. Skin melanoma, eye melanoma(except the conjunctival), melanoma with unknown primary foci;
• •5. The primary lesion is not completely resected;
• •6. Staging examination indicated residual or metastatic tumor;
• •7. Female patients who are pregnant or lactating, or of childbearing potential but not using appropriate contraceptive measures;
• •8. Currently having serious and uncontrolled acute infection; or suppurative infection and chronic infection with prolonged wound healing;
• •9. Having serious heart disorder, including cardiac failure congestive, uncontrollable high-risk arrhythmia, unstable angina pectoris, infarct myocardial, severe cardiac valve disease and refractory hypertension;
• •10. Having neurological, mental disease or mental disorder that can not be easily controlled, poor compliance, inability to cooperate and narrate therapeutic response;
• •11. Patients with other malignant tumors at the same time;
• •12. Patients paticipated in other clinical trials at the same time;
• •13. Positive HIV; positive HCV; positive HBsAg or HBcAb whilst positive HBV DNA copies detected (limit of quantitation 500 IU/mL);
• •14. Active autoimmune diseases requiring systemic treatment in the past two years (e.g., use of disease-regulating drug, corticosteroid or immunosuppressant), relevant replacement therapy is allowed (e.g., thyroxine, insulin or physiological corticosteroid replacement therapy for renal or pituitary insufficiency);
• •15. Having received live vaccine within 4 weeks prior to the start of treatment;
• •16. Other severe, acute or chronic medical diseases or mental diseases or abnormalities in laboratory examination possibly increasing the relevant risk in study participation or possibly interfering the interpretation of study results as judged by the investigators..