Phase IIa Trial of a Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)

Exclusion Criteria

• •Alcohol use that meets criteria for Alcohol Use Disorder in past 3 months.
• •Marijuana or other drug use that meets criteria for Substance Use Disorder in past 3 months.
• •Ever diagnosed with: Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Obsessive-Compulsive Disorder, or Major Depressive Disorder with Psychotic Features
• •Experienced any psychologically traumatic event in the past 3 months
• •Currently using certain antidepressant medications such as doxepin or tricyclics
• •Currently using certain mood stabilizers, such as lithium
• •Currently using antipsychotic medication
• •High risk for suicide or violent behavior
• •Has sleep apnea and not using any treatment, such as CPAP
• •Currently using corticosteroid medication (oral or inhaled)
• •History of neurological disease
• •Angina, congestive heart failure or low blood pressure
• •Heart attack in the past 6 months
• •Heart block or irregular heartbeat
• •Kidney failure, liver failure or pancreatitis
• •Severe chronic obstructive pulmonary disease (COPD)
• •History of liver disease with lab results on AST or ALT more than 2 times the normal readings
• •History of kidney disease with lab results on eGFR less than 60 ml/min
• •History of additional risk factors for Torsades de pointes, such as heart failure, low potassium, or family history of a heart rhythm disorder called long QT syndrome
• •Use of certain medications that can affect heart rhythm
• •Use of certain medications that can interfere with the effects of the study drug
• •High blood pressure that is not controlled by medication
• •Diabetes that is not well-controlled
• •History of certain types of head injuries
• •Mild cognitive impairment