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Immune Homeostasis in Sepsis and Septic Shock | Clinical Trials | Clareo Health

RECRUITING

Immune Homeostasis in Sepsis and Septic Shock

Immune Homeostasis in Patients With Sepsis and Septic Shock: a Single Center Observational Study

NCT04448951•Charles University, Czech Republic

Summary

Detailed description of immune response and its dynamics in sepsis and septic shock patiens by means of transcriptomics, flow-cytometry and cytokine analysis.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•sepsis/septic shock (SEPSIS-3)
•age ≥18
•informed consent
•inclusion within first 24hrs after development/diagnosis of septic shock

Exclusion Criteria

•disagreement of the patient or legal representative with the entry into the study
•patients with primary or secondary immunodeficiency
•presence of active haematological malignancy or an active non-haematological malignancy

Locations (1)

Medical ICU, 1st Dept. of Internal Medicine, Teaching Hospital in Pilsen

Pilsen, Česká Republika, Czechia

Key Dates

Start Date

September 1, 2020

Primary Completion Date

August 31, 2025

Completion Date

December 31, 2027

Last Updated

August 21, 2024

Enrollment

200

ESTIMATED participants

Conditions

SepsisImmunologic ParalysisImmunologic SuppressionImmune Deficiency

Interventions

transcriptomics

OTHER

flow-cytometry

OTHER

cytokines

OTHER

Contacts

Thomas Karvunidis, MD, Ph.D.

CONTACT

+420 377 103 173 karvunidist@fnplzen.cz

Marcela Královcová, MD

CONTACT

+420 377 103 173 kralovcovam@fnplzen.cz

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

NCT04850456

Critical IllnessSepsis, Severe

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RECRUITING

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

NCT04955210

Critical IllnessSevere Sepsis

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 21, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Immune Homeostasis in Sepsis and Septic Shock

Inclusion Criteria

Exclusion Criteria

Treatment Strategy of Human Gamma Globulin on the Therapy for Intensively Ill Children With Inflammatory Storm

A Multi-Center Data System and Collaborative Network in China for Severe Infection and Sepsis Children

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit

African Survey on Sepsis Knowledge (ASK)