Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Danish Dementia Research Centre
With
Zealand University Hospital
Copenhagen University Hospital, Rigshospitalet
University of Aarhus
T&W Engineering A/S
Age
50–90
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Meet the criteria for probable Alzheimer's disease with amnestic presentation as described in the NIA-AA criteria (McKhann 2011)
The diagnosis has been made by either a neurologist, psychiatrist or a geriatrician at the memory clinic at Rigshospitalet or Zealand University Hospital
The participant is between 50 and 90 years old
The MMSE score is between 16-28
The participant does not wear a hearing aid
The participant is a native Danish speaker
The participant has at least attended school for 7 years
The participants' hearing and vision is sufficient to participate in neuropsychological tests
The participants' general condition of health allows that the participant can cooperate with the trial
The participant does not suffer from psychiatric diseases (except mild depressive symptoms or mild depression) or neurological diseases that affect the brain other than Alzheimer's disease
The treatment with anti-dementia medication or SSRI drugs have been given in stable dose for at least 3 months up to the inclusion and the doctor including the participant estimates that treatment will not change within the next 6 months
No overuse of alcohol or intake of illegal drugs within the last 2 years
The participant has previously undergone a CT or MRI scan, which is compatible with Alzheimer's disease
The participant does not have any contraindications for MRI or MRI contrast
The participant is living with another person, who is willing to take part in the trial, and who is together with the person long enough to observe the behavior (if any epileptic activity should arise)
Meet the criteria for Lewy body dementia as described in dementia with Lewy body consortium (McKeith 2017)
The diagnose has been made by either a neurologist, psychiatrist or a geriatrician at the memory clinic at Rigshospitalet or Zealand University Hospital
The participant is between 50 and 90 years old
The MMSE score is between 16-28
The participant does not wear a hearing aid
The participant is a native Danish speaker
The participant has at least attended school for 7 years
The participants' hearing and vision is sufficient to participate in neuropsychological tests
The participants' general condition of health allows that the participant can cooperate with the trial
The participant does not suffer from psychiatric diseases (except mild depressive symptoms or mild depression) or neurological diseases that affect the brain other than Lewy body dementia
The treatment with anti-dementia medication or SSRI drugs have been given in stable dose for at least 3 months up to the inclusion and the doctor including the participant estimates that treatment will not change within the next 6 months
No overuse of alcohol or intake of illegal drugs within the last 2 years
The participant does not have any contraindications for MRI or MRI contrast
The participant is living with another person, who is willing to take part in the trial, and who is together with the person long enough to observe the behavior (if any epileptic activity should arise)
Normal cognition as evaluated at the clinical examination
The participant is a native Danish speaker
The participant has at least attended school for 7 years
The participants' hearing and vision is sufficient to participate in neuropsychological tests
The participants' general condition of health allows that the participant can cooperate with the trial
The participant does not suffer from psychiatric diseases (except mild depressive symptoms or mild depression) or neurological diseases that affect the brain
The participant does not have any contraindications for MRI or MRI contrast
You may not be if
Diagnosis of epilepsy prior to the diagnosis of Alzheimer's disease was made
Other focal pathology in the hippocampus for example hippocampal sclerosis
The person living with the participant is not able to participate (e.g. due to a serious disease or disability) in the clinical visits or able to register behavior suspected of epilepsy
The participant is living in a nursing home
The participant is treated with antiepileptic medication, tricyclic antidepressants or antipsychotics
Daily or nearly daily intake of medication known to have an anticholinergic or an adrenergic effect, which is suspected to affect the cognitive abilities or the EEG
Large brain infarctions or more than 4 lacunar infarcts
The participants is suffering from uncontrollable movements of the face as for example oral dyskinesia
Diagnosis of epilepsy prior to the diagnosis of Lewy body dementia was made
Other focal pathology in the hippocampus for example hippocampal sclerosis
The person living with the participant is not able to participate (e.g. due to a serious disease or disability) in the clinical visits or able to register behavior suspected of epilepsy
The participant is living in a nursing home
The participant is treated with antiepileptic medication, tricyclic antidepressants or antipsychotics
Daily or nearly daily intake of medication known to have an anticholinergic or an adrenergic effect, which is suspected to affect the cognitive abilities or the EEG
Large brain infarctions or more than 4 lacunar infarcts
The participants is suffering from uncontrollable movements of the face as for example oral dyskinesia
The participants is suffering from uncontrollable movements of the face as for example oral dyskinesia
The participant is suffering from epilepsy or receives anti-epileptic medication
