A Randomized Study of Smile Exercise for Dry Eye

Exclusion Criteria

• •1. Corneal fluorescein staining present \>5 score.
• •2. Contact lens wearing history:
• •* Used contact lenses within last 14 days prior to the Screening Visit.
• •* Unwilling to avoid using contact lenses druing the study.
• •3. Any corneal surgery within 12 months before Screening Visit .
• •4. Participation in other medical studies 3 months before screening Visit.
• •5. Current or previous diagnosis of any following ocular conditions in 3 months:
• •i). acute allergic conjunctivitis ii). infection (e.g. bacterial, viral, protozoan or fungal infection of the cornea, conjunctiva, lacrimal gland, lacrimal sac or eyelids) iii). inflammation (e.g., retinitis, macular inflammation, choroiditis, uveitis, scleritis, episcleritis, keratitis)
• •6. Eyelid abnormalities that affect lid function (e.g. lagophthalmos, blepharospasm, ectropion, entropion, severe trichiasis, etc.)
• •7. Extensive ocular surface scarring or condition that may compromise ocular surface integrity such as Stevens-Johnson syndrome, prior chemical burn, recurrent corneal erosions, persistent corneal epithelial defects, prior ocular trauma, etc.)
• •8. Currently diagnosis of glaucoma and under glaucoma medication or surgery treatment
• •9. Currently using, or intent to have any specific treatments for dry eye disease
• •10. Fluorescein sodium allergy
• •11. Pregnant, nursing, or lactating
• •12. Neurological or psychiatric disorders (moderate anxiety, depression and sleep disorders)
• •13. Uncontrolled ocular or systemic diseases
• •14. History of epilepsy .
• •15. The researchers did not consider the patient is appropriate for inclusion in this study
• •16. Cognitive or psychiatric defect that precludes informed consent or ability to perform requirements in the investigation.