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Myotonia and Muscle Stiffness in NMD | Clinical Trials | Clareo Health

COMPLETED

Myotonia and Muscle Stiffness in NMD

Myotonia, Muscle Stiffness and Elasticity in Neuromuscular Disorders

NCT04411732•LMU Klinikum

Summary

The primary objective of this study is to assess stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia. The secondary objectives are (1) to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with dystrophic or non-dystrophic myotonia; to provide reference values for stiffness, muscle tone, relaxation periods and elasticity of various muscles in patients with non-myotonic neuromuscular disorders, (3) assess correlations between to compare result values for stiffness, muscle tone, relaxation periods and elasticity with clinical muscle function tests, measured by clinical evaluation (MRC-scale) and the 6-minute walk test; (4) assess correlations between subcutaneous fat and muscle thickness and echogenicity, measured by muscle ultrasound and result values for stiffness, muscle tone, relaxation periods and elasticity.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•For Patients:
•≥18 years of age
•Confirmed neuromuscular disease
•written consent
•able and willing to perform study prodcedures
•For healthy volunteers:
•age ≥18 years of age
•written informed consent
•no clinical sign for neuromuscular disorders

Exclusion Criteria

•Severe comorbidities
•Patient is participating in another clinical study using investigational treatment
•Patient cannot perform required muscle function tests
•the patient, in the opinion of the investigator, is unable to adhere to the requirements of the study

Locations (1)

Friedrich-Baur-Institute, Dep. of Neurology Klinikum der Universitaet Muenchen

Munich, Bavaria, Germany

Key Dates

Start Date

October 1, 2019

Primary Completion Date

July 31, 2023

Completion Date

September 30, 2023

Last Updated

October 11, 2023

Enrollment

133

ACTUAL participants

Conditions

Neuromuscular Disorders

Interventions

MyotonPro

DEVICE

Six-minute walk test

DIAGNOSTIC_TEST

Semiquantitative muscle ultrasound

DIAGNOSTIC_TEST

Hand-held Dynamometry of muscle strength

DIAGNOSTIC_TEST

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Duchenne Muscular Dystrophy (DMD)Neuromuscular Disorders+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 11, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Myotonia and Muscle Stiffness in NMD

Inclusion Criteria

Exclusion Criteria

Bidirectional Tuning of the AFO Stiffness

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