1. Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

2. Previous history of solid tumor brain metastasis of any origin

3. Histopathological confirmation of the primary solid tumor or a metastatic site

4. Previous radiation therapy of brain metastatic lesion(s)

5. A reference lesion considered by the site investigator to be equivocal for recurrent brain metastasis

6. Patient requires further confirmatory diagnostic procedures to confirm brain MRI findings and is planned for craniotomy

Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE)