Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer

Inclusion Criteria

• •Histologically or cytologically confirmed extensive stage small cell lung cancer (ES-SCLC)
• •Considered suitable to receive a platinum-based chemotherapy regimen with durvalumab as 1st line treatment for ES-SCLC.
• •Measurable disease defined as lesions that can be accurately measured in at least one dimension (longest diameter to be recorded) as ≥ 10 mm with CT scan, as ≥ 20 mm by chest x-ray, or ≥ 10 mm with calipers by clinical exam.
• •At least one lesion must be able to be biopsied at the time of enrollment. The site utilized for biopsy cannot be utilized as a target lesion for efficacy measurement.
• •At least 18 years of age.
• •ECOG performance status ≤ 1
• •Life expectancy of at least 12 weeks.
• •Body weight \> 30 kg.
• •Adequate normal organ and marrow function as defined below:
• •* Hemoglobin ≥ 9.0 g/dL
• •* Absolute neutrophil count ≥ 1.0 K/cumm
• •* Platelet count ≥ 75 K/cumm
• •* Serum bilirubin ≤ 1.5 x institutional upper limit of normal (IULN)
• •* AST (SGOT)/ALT (SGPT) ≤ 2.5 x IULN unless liver metastases are present, in which case it must be ≤ 5 x IULN
• •* Measured creatinine clearance \> 40 mL/min or calculated creatinine clearance \> 40 mL/min by the Cockcroft-Gault formula or by 24-hour urine collection for determination of creatinine clearance
• •Adequate cardiac function defined as QTcF \< 470 ms on 12-lead ECG.
• •Baseline pulse oximetry must be \> 92% on room air.
• •Evidence of post-menopausal status or negative urinary or serum pregnancy test for female pre-menopausal patients. Women will be considered post-menopausal if they have been amenorrheic for 12 months without an alternative medical cause. The following age-specific requirements apply:
• •* Women \< 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and if they have luteinizing hormone and follicle-stimulating hormone levels in the post-menopausal range for the institution or underwent surgical sterilization (bilateral oophorectomy or hysterectomy).
• •* Women ≥ 50 years of age would be considered post-menopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatments, had radiation-induced menopause with last menses \> 1 year ago, had chemotherapy-induced menopause with last menses \> 1 year ago, or underwent surgical sterilization (bilateral oophorectomy, bilateral salpingectomy, or hysterectomy):
• •Male and female patients of reproductive potential must be willing to employ effective birth control from screening to 90 days after the last dose of durvalumab
• •Ability to understand and willingness to sign an IRB approved written informed consent document (or that of legally authorized representative, if applicable). This includes consent for tumor/normal exome sequencing and dbGaP-based data sharing.
• •* Patients with grade ≥ 2 neuropathy will be evaluated on a case-by-case basis after consultation with the PI.
• •* Patients with irreversible toxicity not reasonably expected to be exacerbated by treatment with durvalumab may be included only after consultation with the PI.
• •Radiotherapy treatment to more than 30% of the bone marrow or with a wide field of radiation within 4 weeks of the first dose of study drug.
• •Major surgical procedure (as defined by the PI) within 28 days prior to the first dose of study drug. Note: local surgery of isolated lesions for palliative intent is acceptable.
• •History of allogenic organ transplantation.
• •History of leptomeningeal carcinomatosis.
• •Any known history of brain metastases. Patients with known brain metastases must be excluded from this clinical trial because of their poor prognosis and because they often develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events.
• •A history of allergic reactions attributed to compounds of similar chemical or biologic composition to durvalumab or other agents used in the study.
• •Known allergy, or history of serious adverse reaction to vaccines such as anaphylaxis, hives, or respiratory difficulty.
• •Uncontrolled intercurrent illness including, but not limited to:
• •* uncontrolled ongoing or active infection
• •* a history of myocarditis or congestive heart failure (as defined by New York Heart Association Functional Classification III or IV)
• •* myocardial infarction 6 months prior to study entry
• •* uncontrolled hypertension
• •* unstable angina pectoris
• •* serious uncontrolled cardiac arrhythmia
• •* interstitial lung disease (ILD) or a history of ILD/pneumonitis requiring treatment with systemic steriods
• •* serious chronic gastrointestinal conditions associated with diarrhea
• •* psychiatric illness or social situations that would limit compliance with study requirements, substantially increase the risk of incurring AEs, or compromise the ability of the patient to give written informed consent.
• •Current or prior use of immunosuppressive medication within 14 days before the first dose of durvalumab. The following are exceptions to this criterion:
• •* Intranasal, inhaled, topical steroids, or local steroid injections (e.g. intra-articular injection)
• •* Systemic corticosteroids at physiologic doses not to exceed 10 mg/day of prednisone or its equivalent
• •* Steroids as premedication for hypersensitivity reactions (e.g. CT scan premedication)
• •Receipt of live attenuated vaccine within 30 days prior to the first dose of study drug. Note: patients, if enrolled, should not receive live vaccine whilst receiving study drug and up to 30 days after the last dose of study drug.
• •History of syncopal or vasovagal episode as determined by medical record and history in the 12 month period prior to enrollment
• •Eligible to receive durvalumab
• •ECOG performance status ≤ 1
• •Body weight \> 30 kg
• •Baseline pulse oximetry must be \> 92% on room air