PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

Study Description: This pilot/exploratory study will examine whether cyclooxygenase 1 (COX-1) and COX-2 are elevated in the brain of individuals with neurodegenerative brain disease compared to healthy volunteers. Objectives: Primary Objective: To determine whether COX-1 and/or COX-2 is elevated in the brains of individuals with neurodegenerative brain disease compared to healthy volunteers. Secondary Objective: 1\) To determine retest variability and reliability for each radioligand. 2) To evaluate the specific binding of \[11C\]PS13 to COX-1 in healthy subjects through blocking study using Ketoprofen, a COX-1 inhibitor Endpoints: Primary Endpoint: Measurement of COX-1 and COX-2 density in brain after PET scans with \[11C\]PS13 and \[11C\]MC1, respectively. Secondary endpoint: 1) To measure whole-brain distribution volume (VT) of COX-1 and COX-2 in a retest setting; 2) To correlate VT with the presence of amyloid in Alzheimer s disease (AD) patients, mild cognitive impairment (MCI) patients and healthy volunteers (HV); 3) To calculate the specific binding of \[11C\]PS13 with a Lassen plot