Azienda Ospedaliero Universitaria Policlinico Umberto I, Roma
ASST Cremona, Cremona
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ospedale di Circolo e Fondazione Macchi, Varese
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
SARS-CoV2 Infection diagnosed by rt-PCR
CT-scan confirmed interstitial pneumonia
Hospital admission from less than 24h
P/F ratio \>150 mmHg
Written Informed Consent
You may not be if
Age \<18 ys or \>65
Patients in mechanical ventilation at time of admission
Severe Hearth failure (NYHA 3 or 4)
QTc \> 470 ms or \>500 ms in wide QRS patients
Severe History of Chronic Ischemic Heart Disease, defined as history of Major Adverse Cardiovascular Event and/or recent (one year) revascularization.
History of recurrent Deep Venous Thrombosis and Pulmonary Embolism or established thrombophilic conditions (e.g. history of anti-phospholipid antibodies, …)
Active Bacterial or Fungal Infection
Hematological cancer
Metastatic or intractable cancer
Pre-existent neurodegenerative disease
Severe Hepatic Impairment,
History of acute diverticular disease or intestinal perforation
HBsAg positive and/or HBV-DNA positive patients
Severe Renal Failure (Creatinine Clearance \<30ml/h)
Active Herpes zoster infection
Patients with active or latent TB
Severe anemia (Hb\<9g/dl)
Lymphocyte count below 750/mcl
Neutrophil count below 1000/mcl
Platelet count below 50000/mcl
Pregnancy or Lactation
History of intolerance to the experimental drugs or excipients
Degenerative maculopathy or other relevant retinal disease
Inability to give informed consent (severe transitory or permanent mental impairment, incapacitation)
Clareo Health | TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With COVID-19 Interstitial Pneumonia
