Induction Chemotherapy for Locally Recurrent Rectal Cancer

Exclusion Criteria

• •Radiological evidence of metastatic disease (e.g. liver, lung) at time of randomisation or in the six months prior to randomisation.
• •Known homozygous DPD deficiency
• •Any chemotherapy in the past 6 months.
• •Any contraindication for the planned chemotherapy, as determined by the medical oncologist.
• •Radiotherapy in the past 6 months for primary rectal cancer.
• •Any contraindication for the planned chemoradiotherapy, as determined by the medical oncologist and/or radiation oncologist.
• •Any contraindication for surgery, as determined by the surgeon and/or anaesthesiologist.
• •Concurrent malignancies that interfere with the planned study treatment or the prognosis of resected LRRC.