About Pricing FAQs Blog

Loading clinical trials...

Your health journey, clearly organized.

Find Clinical Trials →

Legal

Privacy Policy
Terms of Service

© 2026 Clareo Health. All rights reserved.

Intraosseous Morphine in Primary TKA | Clinical Trials | Clareo Health

Back to clinical trial search

COMPLETEDPhase 4NCT04388111

Intraosseous Morphine in Primary TKA

The research team wants to investigate if an intraosseous injection (directly into the bone marrow) of morphine during primary total knee replacement helps with post-operative pain following primary t...

Lead sponsor: The Methodist Hospital Research Institute•1 U.S. locations•View source on ClinicalTrials.gov

Clareo plain-language summary

What this study is about

Generating AI summary...

Save this trial guide to your notes

Keep your clinical trial research organized — questions to ask, what to expect, and key details.

Sponsors

Lead Sponsor

The Methodist Hospital Research Institute

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Patient gives informed consent to participate in the study
•Patient is undergoing a primary total knee arthroplasty.
•Age \> 18 and \<80 years old.

Exclusion Criteria

•Patient lacks the capacity to consent to the research project (study will not utilize LAR signatures during the informed consent process)
•Weigh \< 100 pounds
•BMI \> 35
•Pregnancy or suspected pregnancy
•Past medical history of opioid addiction.
•Established hypersensitivity (ie allergy) to morphine.
•Acute or chronic liver disease for example cirrhosis.
•Use of any narcotics 5 days before surgery (opioids, hydrocodone, morphine, hydromorphone, fentanyl, etc).
•Undergoing bilateral total knee replacement, revision total knee arthroplasty, or any additional procedure outside of a primary total knee arthroplasty.
•Unable to get general and spinal anesthesia.

Related studies

RECRUITINGPhase 3

Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain

NCT07226258 · Osteoarthritis Knee Pain

Splinted Wrist Study

NCT07553000 · Wrist Injuries, Wrist Fracture, and more

The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement

NCT05487053 · Osteo Arthritis Knee, Gonarthrosis

MISHA Post-Market Clinical Study

NCT06118892 · Osteo Arthritis Knee

Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine

NCT07134660 · Postoperative Pain, Acute, Lung Cancer

View all related studies →

Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: September 19, 2024Terms

Trial snapshot

StatusCOMPLETED

PhasePHASE4

Enrollment65

Start dateMay 2020

Last updatedSep 19, 2024

Condition

Knee Disease Arthritis Knee Pain, Acute

Locations shown

Houston Methodist Hospital

Houston, Texas

For caregivers

Use Clareo to keep notes, questions, trial details, and next steps organized before and after appointments.

Start free trial →

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 19, 2024Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions