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UNKNOWNNCT04379180

Population Pharmacokinetics and Dosage Individualization of Oral Pulmonary Vasodilators in PPHN

The use of bosentan, sildenafil and tadalafil in neonates with persistent pulmonary hypertension (PPHN) depends mostly on the empirical experience of pediatricians. Moreover, the recommended dose of t...

Lead sponsor: Shandong University•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

Shandong University

Collaborators

West China Second University Hospital

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Age: postnatal age ≤ 28 days;
•Patients have been diagnosed with PPHN;
•Bosentan, sildenafil and/or tadalafil used as part of regular treatment.
•Parental written consent

Exclusion Criteria

•Expected survival time less than the treatment cycle;
•Major congenital malformations;
•Undergoing surgery within the first week of life;
•Receiving other systemic trial drug therapy;
•Other factors that the researcher considers unsuitable for inclusion.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 7, 2020Terms

Trial snapshot

StatusUNKNOWN

Phase—

Enrollment500

Start dateApr 2020

Last updatedMay 7, 2020

Condition

Persistent Pulmonary Hypertension of the Newborn

Locations shown

West China Second University Hospital

Chengdu, Sichuan

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 7, 2020Data synced to Clareo: June 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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