Development of Assessments for Later Stage HD

Inclusion Criteria

• •All Participants
• •1. Individual of either gender
• •2. Fluent in English
• •3. Must be willing and able to provide informed consent or have a legal representative willing and able to provide assent
• •Manifest HDGEC Participants
• •1. Must be an active participant in the Enroll-HD study. An active participant is defined as a participant who has successfully enrolled in the Enroll-HD study and completed the Enroll-HD study baseline visit.
• •2. Age≥20 years
• •3. CAG repeat length≥36
• •4. DCL=4
• •5. Inclusion score of 16 at the time of the participant's most recent Enroll-HD study visit (for inclusion score calculation, see Appendix A - Inclusion Score Calculation) Companion Participants
• •1\. Age≥18 years 2. A person who, in his/her opinion, has sufficient interface and knowledge of the Manifest HDGEC Participant's capabilities and daily activities 3. Acceptable to the Manifest HDGEC Participant and the Site Investigator or the Site Investigator's designees