Sensor-based Characterization of Depression

Exclusion Criteria

• •1. Active drug or alcohol use disorder in the past 3 months,
• •2. History of psychotic disorder,
• •3. History of mania or hypomania,
• •4. Epilepsy or history of Seizure Disorder (including PNES), narcolepsy, Alzheimer Disease, Parkinson's Disease, ALS, Severe TBI, Dementia, MS, Cerebral Palsy, and Neuralgia.
• •5. Untreated hypothyroidism,
• •6. Unstable medical disease,
• •7. Cognitive impairment that would impede adherence to study procedures,
• •8. Acute suicide or homicide risk,
• •9. Current treatment with electroconvulsive therapy, vagal nerve stimulation therapy, deep brain stimulation, transcranial magnetic stimulation therapy, or phototherapy,
• •10. Cannot comprehend or communicate in English,
• •11. Lack of working smartphone or lack of daily access to Internet service,
• •12. Inability to measure skin conductance/electrodermal activity (as assessed at the screening visit), and
• •13. Inability or unwilling to, at minimum, wear the physiological sensor (E4) wristbands, download monitoring apps, and fill out the surveys.
• •14. Participants with more than two treatment failures (more than two adequate trials of meds on the basis of ATRQ) in the current mood episode.