Hospitalized patients with illness of any duration, and/or SpO2 ≤ 92% on room air.
Cohorte C : patients with cancer (hematological malignancies and solid tumors).
You may not be if
Refusal to participate,
Any immunosuppressive therapy (i.e. corticosteroids \>10mg of hydrocortisone or equivalent dose) within 14 days before the planned start of study,
Active or chronic hepatitis B or C and/or HIV positive (HIV 1/2 antibodies patients), or a known history of active Tuberculosis bacillus,
Active autoimmune disease that required a systemic treatment, with the following exceptions:
* Patients with a history of autoimmune-related hypothyroidism who are on thyroid replacement hormone are eligible for the study,
* Patients with controlled Type 1 diabetes mellitus who are on an insulin regimen are eligible for the study,
Prior allogeneic bone marrow transplantation or prior solid organ transplantation,
Patients currently exposed to chemotherapy, anti-tumor immunotherapy as anti-PD-1, anti-PD-L1, or anti-CTLA4 agent or any immune therapy or biotherapy (except for patients in cohort C),
Previous prescribing of biotherapy or treatment for the management of COVID-19 is not an exclusion criterion,
Patient under guardianship, curatorship or under the protection of justice.
