Women who are pregnant or breastfeeding / have the intention to become pregnant during the course of the study

Other clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.)

Known or suspected non-compliance, drug or alcohol abuse

Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant

Enrolment of the investigator, his/her family members, employees and other dependent persons

Cognitive impairment Mini-Mental State Examination (MMSE) \< 21

Major Depression or Hospital Anxiety and Depression Scale (HADS) \>11 at baseline

Stem cell treatment in the last 6 months

Participation in a previous high-intensity interval training (HIIT) or inpatient energy management education (IEME) study

Training and Energy Management Education to Improve Quality of Life in Persons With Multiple Sclerosis