Improving Theempowerment in Patients With Severe Breast Fibrosis Radio-induced Treated by Pravastatin : Benefit of e-PROs (Electronic " Patient Reported Outcome ") on Breast-related Quality of Life

Exclusion Criteria

• •1. Any breast cancer recurrences
• •2. Current treatment by : statin, fibrate, ciclosporin, systemic fusidic acid, long-term treatment by corticoids
• •3. History of muscular dystrophy diseases or chronic and/or hereditary muscular diseases
• •4. Untreated hypothyroidism
• •5. Serum creatinine \> 130 µmol/l; ASAT and ALAT \> 2N; total bilirubin \> 1.5N
• •6. CK levels \> 3 x ULN in women over 70 years
• •7. Known positive test for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAG) or hepatitis C virus (HCV) antibody
• •8. Pregnant or breastfeeding women
• •9. Women of childbearing potential who are unwilling to employ adequate contraception, from the beginning of the study to 4 weeks after last treatment dose
• •10. Known hypersensitivity to pravastatin, or any constituent of the product.
• •11. Patient with alcohol misuse.
• •12. Patients treated with systemic investigational drugs within the past 30 days
• •13. Legal incapacity or physical, psychological or mental status interfering with the patient's ability to sign the informed consent or to terminate the study.