Pregnancy, breastfeeding mothers, and women of childbearing age who are unable to use 2 forms of contraception, which includes:

* Intrauterine devices (IUD), contraceptive implants, or tubal sterilization

* Hormone methods with a barrier method

* Two barrier methods

* If a partner's vasectomy is the chosen method of contraception, a hormone or barrier method must also be used in conjunction

Co-administration of Cytochrome P450 3A4 (CYPA3A4) and P-glycoprotein (P-gp) transport system inhibitors

Concurrent use of strong CYP3A4 or P-gp inhibitors in patients with renal or hepatic impairment;

Severe hematologic or neuromuscular disorders

Severe renal impairment with concomitant hepatic impairment

Colchicine to Reduce Cardiac Injury in COVID-19 (COLHEART-19)