Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hospices Civils de Lyon
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults aged 18 years or older
ARDS according to the Berlin definition
COVID-19 pneumonia confirmed by RT-PCR
Acute respiratory failure not fully explained by left ventricular failure or sodium overload
Bilateral pulmonary radiological opacities not fully explained by pleural effusions or atelectasis or nodules
Invasive mechanical ventilation with PaO2/FiO2 ≤ 150 mm Hg and PEEP ≥ 5 cm H2O with a tidal volume below or equal to 6 ml per kilogram of predicted body weight
Continuous intravenous sedation as part of ARDS treatment
You may not be if
* ARDS onset more than 48 hours before inclusion
* previous inclusion in present study
* arterial pH \< 7.21 despite respiratory rate set to 35/min at the time of inclusion
* patient under any extracorporeal CO2 removal technique or ECMO
* pneumothorax or bronchopleural fistula
* suspected intracranial hypertension
* severe chronic obstructive pulmonary disease defined by a GOLD score ≥ 3
* chronic respiratory failure under home oxygen or non-invasive ventilation
* chronic respiratory failure requiring long term oxygen or non-invasive ventilation
* obesity with body weight over height ratio greater than 1 kg/cm
* sickle cell disease
* bone marrow transplant \< 6 months
* burn injury with extension greater than 30% of body surface area
* cirrhosis with Child-Pugh score C
* advance directives to withhold or withdraw life sustaining treatment
* Patient under an exclusion period relative to participation to another clinical trial, or inclusion into a clinical trial interfering with the ventilatory strategies
* pregnancy, lactating women
* patient under a legal protective measure.
* lack of affiliation to social security as required by French regulation
* lack of written informed consent by patient or next of kin (unless if recourse to the emergency procedure in the absence of a loved one)
Clareo Health | Ultraprotective Ventilation Without Extracorporeal Circulation During COVID 19 Pneumonia
