1. Patients between 18 and 675 years old included in the CORIMUNO-19 cohort
2. Patients belonging to one of the 2 following groups
* Group 1: 60 patients not requiring ICU at admission with moderate and severe pneumopathy according to the WHO Criteria of severity of COVID pneumopathy, meeting all of the 2 following criteria:
* Respiratory symptoms with radiological findings of pneumonia
* Severe pneumonia requiring ≥ 5L/min of oxygen to maintain SpO2 \>97%
* Group 2: 60 patients requiring ICU based on Criteria of severity of COVID pneumopathy.
* Respiratory failure and requiring mechanical ventilation
* Vasopressive support
3. Vaccinated against meningococcal infections within 3 years prior to, or at the time of, initiating Eculizumab to reduce the risk of meningococcal infection (N meningitidis) \[(Bexsero® (2 injections with a minimum of 1 month interval) + Menveo@ or Niminrex® ) and daily antibiotics (Oracilline®)\]. If vaccination cannot be confirmed or if the patient cannot receive it, the participant should receive prophylactic antibiotics against meningococcal infection prior to initiating Eculizumab treatment and for at least 3 months from the last infusion of Eculizumab.
4. Female patients of childbearing potential and male patients with female partners of childbearing potential must follow protocol-specified guidance for avoiding pregnancy while on treatment and for 8 months after last dose of Eculizumab.
5- Body weight ≥40 kg
6-Patient and/or alternatively by next-of-kin must be willing and able to give written informed consent according to the applicable regulations including emergency and intensive care contexts
You may not be if
Age ≥ 70 years
Pregnancy or lactation
History or unresolved Neisseria meningiditis infection
Ongoing sepsis, presence or suspicion of active and untreated systemic bacterial infection prior study screening and untreated with antibiotics,
Hypersensitivity to any ingredient contained in Eculizumab, including hypersensitivity to murine proteins.
Clareo Health | CORIMUNO19-ECU: Trial Evaluating Efficacy and Safety of Eculizumab (Soliris) in Patients With COVID-19 Infection, Nested in the CORIMUNO-19 Cohort
