Expanded Access to Convalescent Plasma for the Treatment of Patients With COVID-19

Inclusion Criteria

• •Age at least 18 years
• •Laboratory confirmed diagnosis of infection with SARS-CoV-2
• •Admitted to an acute care facility for the treatment of COVID-19 complications
• •Severe or life threatening COVID-19, or judged by the treating provider to be at high risk of progression to severe or life-threatening disease
• •Informed consent provided by the patient or healthcare proxy
• •Severe COVID-19 is defined by one or more of the following:
• •dyspnea
• •respiratory frequency ≥ 30/min
• •blood oxygen saturation ≤ 93%
• •partial pressure of arterial oxygen to fraction of inspired oxygen ratio \< 300
• •lung infiltrates \> 50% within 24 to 48 hours
• •Life-threatening COVID-19 is defined as one or more of the following:
• •respiratory failure
• •septic shock
• •multiple organ dysfunction or failure