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Role of suPAR in Periodontitis and CVD | Clinical Trials | Clareo Health

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COMPLETEDNCT04335344

Role of suPAR in Periodontitis and CVD

soluble urokinase-type plasminogen activator receptor (suPAR) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and cardiovascular disease (CVD). Th...

Lead sponsor: University of Messina•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University of Messina

Collaborators

University of Catania

The aim of this study was to evaluate a possible association between both saliva and serum suPAR levels in patients with CP and with CVD and if the serum suPAR levels are mediated by serum CRP.

Age

40 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Presence of at least 15 teeth
•CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
•Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
•Presence of ≥40% sites with bleeding on probing (BOP)

Exclusion Criteria

•Intake of contraceptives
•Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
•Status of pregnancy or lactation
•Previous history of excessive drinking
•Allergy to local anaesthetic
•Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: April 7, 2020Terms

Trial snapshot

StatusCOMPLETED

Phase—

Enrollment326

Start dateFeb 2015

Last updatedApr 7, 2020

Condition

Metabolic Disturbance Periodontal Diseases

Locations shown

University of Messina

Messina

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 7, 2020Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions