Hydroxychloroquine in Outpatient Adults With COVID-19

Exclusion Criteria

• •COVID-19 disease requiring the use of supplemental oxygen
• •Electrocardiogram (ECG) tracing with QTc interval \> 450 ms for men, \> 470 ms for women (Fridericia algorithm recommended)
• •Bradycardia (\< 50 beats/min)
• •History of cardiac disease (eg. congestive heart failure, myocardial infarction)
• •History of Glucose-6-phosphate dehydrogenase (G6PD) deficiency
• •Women who are pregnant or breastfeeding
• •Concurrent antimicrobial therapy
• •Known hypersensitivity to hydroxychloroquine or other 4-aminoquinoline compounds
• •Hydroxychloroquine use within 2 months before enrollment
• •History of severe skin reactions such as Sevens-Johnson syndrome and toxic epidermal necrolysis
• •History of retinopathy
• •History of arrythmia, concurrent use of anti-arrhythmic drugs, or family history of sudden cardiac death
• •History of severe renal disease (treatment with dialysis or phosphate binders) or hepatic impairment
• •The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.